Electrophysiological effects are similar
By contrast to quinidine, procainamide
does not exhibit either vagolytic or
alpha-adrenergic blocking activity.
Useful in acute management of
supraventricular and ventricular arrhythmias.
Long term use is associated with side
effects, including a drug-induced lupus syndrome
which occurs at a frequency of 25% to 50%. In
slow acetylators the procainamide-induced lupus
syndrome occurs more frequently and earlier in
therapy than in rapid acetylators.