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Procainamide[pro kane a' myde]:
(Class IA, Sodium Channel Blocker)
  • Electrophysiological effects are similar to quinidine.

  • By contrast to quinidine, procainamide does not exhibit either vagolytic or alpha-adrenergic blocking activity.

  • Useful in acute management of supraventricular and ventricular arrhythmias.

  • Long term use is associated with side effects, including a drug-induced lupus syndrome which occurs at a frequency of 25% to 50%. In slow acetylators the procainamide-induced lupus syndrome occurs more frequently and earlier in therapy than in rapid acetylators.