Medical Pharmacology: Drugs Used to Manage Depression

**Corpus Callosum and Hippocampus¹²²**

Attribution: Droual R Brain Stem Model: Corpus Callosum & Hippocampus https://www.youtube.com/watch?v=YJLHDPTrUYk drbobrd YouTube Channel: https://www.youtube.com/channel/UC15YK7pMCRkJOrjOq0Qu5qA

**Human brain autoradiography illustrating NET localization, using a PET scan probe specific for the norepinephrine transporter.¹³⁰**

Human brain autoradiography using the PET ligand (S,S)-[¹⁸F]FMeNER-D₂. Highest intensity is noted in the locus ceruleus and binding is also seen in temporal cortex (TC), cerebellum (Ce), and Pons (Po).	Non-specific binding, to sites other than the NET transporter is assessed by incubating the brain slices with the PET probe in the presence of high concentrations of desipramine. In this setup the higher concentrations of desipramine should occupy the NET sites and any other binding observed is attributed to non-NET, i.e. non-specific sites.

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