Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Which one(s) of the following represent/represents (a) major category/categories of mechanisms of action relating to anti--seizure medications?
1. Drug-induced inactivation of voltage-activated sodium channels.
2. Inhibition of GABA-mediated synaptic inhibition
3. Inhibition of voltage-activated calcium channels associated with the T-type calcium currents
4. A & B
5. A & C
6. A, B & C
Which mechanism(s) of anti-seizure medication appear to mediate pharmacological efficacy against the most common manifestations of epilepsy.
1. Enhancement ofthe inactivated state of voltage-activated sodium channels
2. Augmenting GABA-mediated synaptic inhibition
3. Inhibiting voltage-activated calcium channels associated with T-type calcium currents.
4. A & B
5. B & C
6. A & C
7. A, B & C
An absence seizure (petit mal) is an example of a generalized seizure
1. True
2. False
A partial (focal) seizure, such as "simple partial" is associated with preservation of consciousness.
1. True
2. Paul's
Status epilepticus has been defined as a seizure lasting continuously for 5-30 min.
1. True
2. False
Since control of a given seizure type in a patient is predictable based on attainment of a specific serum drug level defined by the seizure type, appropriate treatment is assured with the attainment of this drug level.
1. True
2. False
An advantage of treating absence seizures is that the seizure is notable in that it responds to most drugs used for both generalized tonic-clonic and complex partial seizures.
1. True
2. False
Most seizures are controllable with monotherapy-i.e. therapy using only one drug.
1. True
2. False
Actions of most anticonvulsive agents:
1. Mediating inhibitory (GABA-related) synaptic transmission in the brain
2. Inhibiting excitatory synaptic neurotransmission in the brain, mediated by the neurotransmitter glutamate.
3. Both
4. Neither
This drugs is indicated only for management of partial seizures.
1. Topiramate
2. Perampanel
3. Zonisamide
4. Ethosuxamide