Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Which ones() of the following seizure categories is NOT effectively managed by phenytoin (diphenylhydantoin, Dilantin)?
1. Absent seizures
2. Partial seizures
3. Tonic-clonic seizures
Nonsedative anti-seizure agent:
1. Phenobarbital
2. Phenytoin
Phenytoin clinical effectiveness:
1. General tonic-clonic seizures
2. Partial seizures
3. Both
4. Neither
Once a day dosing of phenytoin is available with extended-release formulations (oral).
1. True
2. False
Which one(s) of the following statements concerning phenytoin pharmacokinetics is/are correct?
1. Phenytoin pharmacokinetics are affected by phenytoin binding to serum proteins.
2. Phenytoin pharmacokinetics is influenced by activity of the cytochrome P450 microsomal metabolizing system.
3. Both
4. Neither
Valproate administration given along with phenytoin increases free (non-protein-bound) phenytoin due to which one(s) of the following mechanisms?
1. Valproate competition with phenytoin for protein binding sites.
2. Inhibition of phenytoin metabolism
3. Both
4. Neither
Phenytoin pharmacokinetics is unusual in that elimination rate is dependent upon drug concentration.
1. True
2. False
Which one(s) of the following statements concerning phenytoin metabolism is/are correct?
1. Mostly phenytoin is metabolized by the hepatic microsomal system
2. The principal phenytoin metabolite is inactive
3. The metabolism of phenytoin is NONSATURABLE.
4. A & B
5. B & C
6. A, B & C
Concerning phenytoin administration in this setting of contraception: which one(s) of the following statements is/are correct?
1. Phenytoin administration enhances oral contraceptive metabolism, potentially leading to unplanned pregnancy.
2. Phenytoin itself has been associated with teratogenic effects.
3. Both
4. Neither
The most common indication of phenytoin toxicity in children and young adolescents:
1. Hypothyroidism
2. Gingival (gum) hyperplasia
3. Hyperuremic states
4. Hyponatremia