Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Fosphenytoin is phenytoin prodrug which is more soluble then the parent compound.
1. True
2. False
Adverse effect(s) associated with phenytoin administration:
1. Osteomalacia
2. Morbilliform rash
3. Stevens-Johnson syndrome
4. Toxic epidermal necrolysis
5. A & C
6. A, B & C
7. A, B, C & D
Mothers receiving phenytoin during pregnancy may give birth to newborns who exhibit hypoprothrombinemia and hemorrhage.
1. True
2. False
Concerning the dose-dependent phenytoin elimination kinetics:
1. At low phenytoin concentration first-order kinetics is observed
2. At higher doses still within the therapeutic range, hepatic metabolizing system saturation begins to occur
3. Both
4. Neither
Phenytoin half-life:
1. 1-3 hours
2. 5-10 hours
3. 12-36 hours
4. 72 hours
Phenytoin bioavailability and absorption rate is generally independent of the particular preparation.
1. True
2. False
May be effective in treating trigeminal neuralgia:
1. Phenytoin
2. Carbamazepine
3. Both
4. Neither
Most frequently encountered cause for low phenytoin plasma levels:
1. Increased phenytoin metabolism as a result of administration of other drugs.
2. Decreased intestinal absorption
3. Poor patient compliance
Phenytoin administration may reduce the reliability of thyroid function screening tests.
1. True
2. False
Long-term effects of phenytoin treatment include/includes:
1. Facial feature coarsening
2. Some peripheral neuropathy
3. Both
4. Neither