Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Which one(s) of the following drugs (phenytoin-like) they appear efficacious in the management of both partial seizures in generalized tonic-clonic seizures?
1. Mephenytoin
2. Ethotoin
3. Both
4. Neither
Choose (the) correct statement(s) concerning the pharmacology of ethotoin.
1. May be appropriate for patients exhibiting phenytoin hypersensitivity.
2. Ethotoin may be less effective compared to phenytoin
3. Ethotoin associated adverse effects/toxicities appear less severe compared to those noted with phenytoin administration.
4. Ethotoin associated adverse effects/toxicities appear less severe compared to those noted with phenytoin administration.
5. A & B
6. B only
7. B & C
8. A only
9. A & C
10. A, B & C
Within the therapeutic dosage range, mesantoin and ethotoin both exhibit saturable, zero order kinetics, as noted with phenytoin.
1. True
2. False
Most of the anti-seizure effectiveness of mesantoin is due to its metabolite, Nirvanol.
1. True
2. False
Possible indication(s) for the therapeutic use of carbamazepine include(s):
1. Seizures
2. Management of bipolar depressive disorder
3. Trigeminal neuralgia
4. A & B
5. B & C
6. A, B & C
Choose the correct statement(s) concerning carbamazepine clinical utility/utilities.
1. Agent of choice in treating generalized tonic-clonic seizures and partial seizures
2. Carbamazepine when administered in typical therapeutic doses is often highly sedating.
3. Higher doses administered to elderly patients may be associated with unsteadiness and ataxia
4. A & B
5. B & C
6. A & C
7. A, B & C
Half-life following a single initial dose of carbamazepine:
1. 3 hours
2. 9 hours
3. 12 hours
4. 36 hours
Most common dose-related carbamazepine adverse effects: ataxia and diplopia.
1. True
2. False
Most common idiopathic reaction to carbamazepine administration: erythematous skin rash.
1. True
2. False
Idiopathic blood dyscrasias associated with carbamazepine administration may occur and may include potentially fatal aplastic anemia and agranulocytosis.
1. True
2. False