Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Which one(s) of the following statements concerning oxcarbazepine is/are correct?
1. Oxcarbazepine is clinically helpful in managing the same types of seizures as carbamazepine.
2. Oxcarbazepine may exhibit a better toxicity profile compared to carbamazepine.
3. Both
4. Neither
Oxcarbazepine exhibits increased potency compared to carbamazepine such that clinical doses may have to be decreased by about 50% in order to attain comparable seizure control.
1. True
2. False
Choose (the) correct statement(s) concerning the pharmacology of eslicarbazepine.
1. Eslicarbazepine acetate is a prodrug.
2. Eslicarbazepine may be used as adjunct therapy for adults exhibiting partial-onset seizures.
3. The active metabolite for eslicarbazepine acetate is S(+)-licarbazine (eslicarbazepine)
4. A & B
5. B & C
6. A & C
7. A, B & C
Oral contraception may be reduced in efficacy when administered con currently with eslicarbazepine.
1. True
2. False
Phenobarbital (luminol) is historically noted as the first effective organic antiseizure drug.
1. True
2. False
Most barbiturates exert highest anti-seizure activity at doses above those needed for hypnosis (sleep).
1. True
2. False
Seizure inhibition by phenobarbital is mainly dependent on interaction with this receptor system.
1. Cholinergic
2. Adrenergic
3. Glutaminergic
4. GABAergic
Concerning oral administration of phenobarbital:
1. Absorption is complete
2. Absorption occurs relatively slowly
3. Both
4. Neither
The most frequently noted undesired, adverse effect of phenobarbital is sedation, especially prominent during therapy initiation.
1. True
2. False
This/these adverse effect(s) appear associated with phenobarbital administered at excessive doses.
1. Ataxia
2. Nystagmus
3. Both
4. Neither