Medical Pharmacology Practice Questions: Anti-Seizure; Anti-Epileptic Drugs

Derivatives of barbituric acid useful in management of seizures:
1. Mephobarbital
2. Phenobarbital
3. Metharbital
4. Primidone
5. A, B & C
6. A, B & C
7. A, B, C, & D
8. A, B, C, & D
Actions of phenobarbital as an antiseizure medication is likely dependent on:
1. Enhancement of CNS inhibitory systems
2. Attenuation of excitatory CNS systems
3. Both
4. Neither
Seizure most likely to be responsive to phenobarbital treatment:
1. Absent seizures
2. Partial seizures
3. Infantile spasms
4. Atonic seizures
Choose the correct statement(s) concerning the metabolism of primidone:
1. Primidone is metabolized to phenobarbital
2. Primidone is metabolized to phenylethylmalonamide (PEMA)
3. Primidone, phenylethylmalonamide, and phenobarbital are all effective anticonvulsants.
4. A & C
5. B & C
6. A, B & C
Primidone is clinically effective for management of generalized tonic-clonic seizures as well as partial seizures and may be more effective compared to phenobarbital treatment.
1. True
2. False
This agent may be effective in certain patients exhibiting partial seizures; however the drug may result in severe hepatitis and aplastic anemia.
1. Meprobamate
2. Felbamate
3. Primidone
4. Methohexital
Anti-seizure effect(s) of felbamate:
1. Partial seizures
2. Seizures associated with Lennox-Gastaut syndrome
3. Both
4. Neither
Gabapentin and pregabalin act directly on GABA receptors.
1. True
2. False
Gabapentin is an anti-seizure medication which exhibits efficacy against partial seizures.
1. True
2. False
Non-seizure related application(s) associated with the drug gabapentin
1. Management of neuropathic pain
2. Treatment of postherpetic neuralgia and adults
3. Both
4. Neither