Question # 1 (Multiple Choice) Reason that dopamine itself is not used to treat in Parkinson's disease:

A) too expensive
B) the problem is cholinergic in nature
C) dopamine does not cross the blood-brain barrier
D) levodopa has a higher affinity for the D2 receptor

Question # 2 (Multiple Choice) Dominantly inherited disease: associated with progressive chorea and dementia; related to neurotransmitter imbalance

A) Wilson's disease
B) tardive dyskinesia
C) Tourette's syndrome
D) Huntington's disease
E) Shy-Drager syndrome

Question # 3 (Multiple Choice) Antiviral drug found to have anti-Parkinson's properties:

A) procyclidine
B) pergolide
C) amantadine
D) levodopa
E) reserpine

Question # 4 (True/False) Benefits of dopaminergicanti--Parkinson's drugs probably due to stimulation of D2 dopamine receptors

A) true
B) false

Question # 5 (Multiple Choice) Irregular, unpredictable, involuntary muscle contractions:

A) athetosis
B) dystonia
C) tics
D) chorea
E) akinesia

Question # 6 (Multiple Choice) Dopamine agonist ergot derivative -- stimulates D1 & D2 receptors

A) levodopa
B) amantadine
C) pergolide
D) selegiline
E) trihexyphenidyl

Question # 7 (Multiple Choice) Characterized by chronic, multiple tics:

A) Parkinson's disease
B) Wilson's disease
C) Shy-Drager syndrome
D) Tourette's syndrome
E) all of the above

Question # 8 (Multiple Choice) Percentage of levodopa that enters the brain unaltered

A) 1-3%
B) 5-10%
C) 15-30%
D) > 50%

Question # 9 (Multiple Answer) Effective in managing essential tremor

A) propranolol
B) metoprolol
C) primidone
D) diazepam
E) chlordiazepoxide

Question # 10 (Multiple Choice) First-line anti-Parkinson drug; also used to treat hyperprolactinemia at lower doses

A) amantadine
B) levodopa
C) bromocriptine
D) selegiline
E) benztropine mesylate

Question # 11 (Multiple Choice) Carbidopa is useful in the management of Parkinson's disease because it is an: