Nursing Pharmacology Chapter 29:  Diabetes

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Properties of IDDM* and NIDDM**

Characteristic

IDDM

NIDDM

Genetic locus

Chromosome 6

unknown

Typical age of onset

Usually < 40 years of age

> 40 years of age

Plasma insulin

Low to absent

Normal to high

Plasma glucagon

High, suppressible

High, resistant

Acute complication

Ketoacidosis

Hyperosmolar coma

Insulin therapy

Responsive

Responsive to resistant

Response to sulfonylurea drugs

Unresponsive

Responsive

* Insulin-dependent diabetes mellitus

**Non-insulin dependent diabetes mellitus

 

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