Question # 1 (Multiple Choice) More likely to affect the cytochrome P450 drug metabolizing system:

A) ranitidine (Zantac)
B) cimetidine (Tagamet)

Question # 2 (Multiple Choice) Only class of antiulcer drugs that can eradicate Helicobacter pylori and cure associated gastritis:

A) sucralfate (Carafate)
B) colloidal bismuth
C) H2 blockers
D) Anticholinergic agents

Question # 3 (Multiple Choice) Antacid: melt-alkali syndrome:

A) aluminum hydroxide
B) magnesium hydroxide
C) calcium carbonate
D) sodium bicarbonate

Question # 4 (True/False) Reduces basal unstimulated gastric acid secretion; enhanced mucosal resistance to injury-- prostaglandins (PGE1/PGE2)

A) true
B) false

Question # 5 (Multiple Choice) Antacid: effective, but associated with systemic alkalosis

A) calcium carbonate
B) sodium bicarbonate
C) magnesium hydroxide
D) aluminum hydroxide

Question # 6 (Multiple Choice) Antacid: most likely to cause systemic phosphate depletion:

A) sodium bicarbonate
B) calcium carbonate
C) magnesium hydroxide
D) aluminum hydroxide

Question # 7 (Multiple Choice) Monotherapy effectiveness in eradication of H. pylori-- bismuth compounds

A) 5%
B) 20%
C) 50%
D) 90%

Question # 8 (Multiple Answer) Omeprazole (Prilosec) and lansoprazole approved for clinical treatment of:

A) duodenal ulcer
B) erosive gastritis
C) Zollinger-Ellison syndrome and other gastric acid hypersecretory states

Question # 9 (Multiple Choice) Side effect profile-- antiulcer medication: urinary retention, blurred vision, xerostromia,:

A) ranitidine (Zantac)
B) atropine
C) nifedipine (Procardia, Adalat)
D) sucralfate (Carafate)

Question # 10 (Multiple Answer) Examplesof H2 (histamine receptor Type II) antagonists:

A) cimetidine (Tagamet)
B) ranitidine (Zantac)
C) nizatidine (Axid)
D) famotidine (Pepcid)
E) terfenadine

Question # 11 (Multiple Choice) Mechanism of action: cytoprotection, binds to the ulcer base, antibacterial effect:

A) metronidazole (Flagyl)
B) tetracycline (Achromycin)
C) bismuth compounds
D) ranitidine (Zantac)
E) omeprazole (Prilosec)

Question # 12 (Multiple Answer) Drug(s) used iin eradication of Helicobacter pylori infection:

A) bismuth compounds
B) metronidazole (Flagyl)
C) clarithromycin (Biaxin)
D) omeprazole (Prilosec)
E) amoxicillin (Amoxil Polymox)

Question # 13 (Multiple Choice) Most widely used antacid in treating ulcer disease:

A) sodium bicarbonate
B) calcium carbonate
C) magnesium hydroxide
D) aluminum hydroxide
E) combination of aluminum hydroxide and magnesium hydroxide

Question # 14 (Multiple Choice) Treatment of gastric a disease: atropine vs.H2-receptor blockers -- atropine is:

A) more effective than H2 receptor blockers
B) less effective than H2 receptor blockers
C) equally effective

Question # 15 (Multiple Choice) Drawbacks of "triple therapy" {bismuth compounds + metronidazole (Flagyl) + tetracycline (Achromycin)}in treating peptic ulcer disease:

A) patient compliance (2 week treatment = 200 tablets)
B) side effects
C) both
D) neither

Question # 16 (Multiple Choice) Antacid: constipation

A) aluminum hydroxide
B) magnesium hydroxide

Question # 17 (Multiple Choice) Most successful protocol for eradication of H. pylori/treatment of peptic ulcer disease:

A) bismuth monotherapy
B) therapy using bismuth compounds, metronidazole (Flagyl), and amoxicillin (Amoxil Polymox) in combination -triple therapy
C) bismuth compounds and amoxicillin (Amoxil Polymox)
D) all of the above equally effective

Question # 18 (Multiple Choice) Antacid: loose stools

A) aluminum hydroxide
B) magnesium hydroxide
C) both
D) neither

Question # 19 (Multiple Choice) Eradication of H. pylori effectiveness for bismuth compounds when using combination with antibiotics:

A) 5%
B) 20%
C) 50%
D) 80%
E) 95%