Gonadal Hormones and Inhibitors: Question Set #7

Orally active 5-alpha reductase inhibitor; moderately effective in reducing prostate size in men with benign prostatic hyperplasia
1. flutamide
2. spironolactone (Aldactone)
3. finasteride
4. cyproterone
5. all of the above
Used for treating advanced prostatic carcinoma; works by producing continuous gonadal suppression; is a gonadotropin-releasing hormone analog
1. ketoconazole (Nizoral)
2. methyltestosterone
3. leuprolide acetate
4. stanozolol
Most rapidly absorbed:
1. testosterone propionate
2. testosterone
3. testosterone enanthate
4. testosterone undecanoate
5. testosterone cypionate
Clinical uses of androgens:
1. certain gynecologic disorders, such as endometriosis
2. protein anabolic agent
3. osteoporosis
4. androgen replacement and hypogonadal men
5. all of the above
Estrogen effects on lipid metabolism:
1. decrease serum triglycerides
2. decrease free cholesterol
3. decrease esterified cholesterol
4. decrease low-density lipoproteins
5. all of the above
Aromatase inhibitor -- selective nonsteroidal form
1. danazol (Donocrine)
2. clomiphene (Clomid)
3. anastrozole (Arimidex)
4. norethindrone (Aygestin)
Physiological effects of progesterone:
1. decreases basal insulin levels
2. decreases insulin response to glucose
3. decreases glycogen storage
4. decreases ketogenesis
5. none of the above
Oral contraceptive effects on endocrine function except:
1. increases corticosteroid-binding globulin
2. increases plasma renin activity
3. increases aldosterone secretion
4. increases ACTH response to metyrapone
5. increases thyroxine levels
Most likely to be produced in quantity in the testes:
1. androstenedione
2. dehydroepiandrosterone
3. dehydroepiandrosterone sulfate
4. testosterone
Dihydrotestosterone: dominant androgen
1. skin
2. seminal vesicles
3. prostate
4. epididymis
5. all of the above