Nursing Pharmacology Chapter 21:  Histamine

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H2 Receptor Antagonists

 

Pharmacodynamics: H2 Receptor Antagonists

 

Clinical Uses: H2 Receptor Antagonists

Cimetadine inhibits clearance of these agents (partial listing):

 warfarin

 phenytoin (Dilantin)

 propranolol (Inderal)

 metoprolol (Lopressor)

 labetalol (Trandate, Normodyne)

 Quinidine gluconate (Quinaglute, Quinalan)

caffeine

 lidocaine (Xylocaine)

theophylline

 alprazolam (Xanax)

 triazolam (Halcion)

chlordiazepoxide (Librium)

carbamazepine (Tegretol)

ethanol

tricyclic antidepressants

 metronidazole (Flagyl)

calcium channel blockers

 sulfonylureas

 diazepam (Valium)

 flurazepam (Dalmane)

 

  1. Burkhalter, A, Julius, D.J. and Katzung, B. Histamine, Serotonin and the Ergot Alkaloids (Section IV. Drugs with Important Actions on Smooth Muscle), in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 261-286.

  2. Friedman, L. S. and Peterson, W.L. Peptic Ulcer and Related Disorders In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., and Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp. 1597-1616.

 

 

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