TH1--Cell-mediated Immunity

• produces interferon-g (IFNg)

• produces interleukin-2 (IL-2)

• produces tumor necrosis factor-b (TNFb)

• induces cell-mediated immunity by activation of:

  • cytotoxic T cells (CTL)

  • natural killer (NK) cells

  • macrophages

• IL-10 (from TH2 cells) down regulates TH1 activity

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