Question # 1 (True/False) Uterine sensitivity to ergot alkaloids increases as pregnancy progresses:

A) true
B) false

Question # 2 (Multiple Answer) Migraine: clinical presentations/characteristics

A) usually unilaterall headache
B) associated with stress
C) equally common in women and men
D) may be accompanied by a brief aura

Question # 3 (Multiple Choice) Vasoconstriction-- bradykinin

A) arteriolar vascularl smooth muscle
B) venular smooth muscle

Question # 4 (Multiple Choice) Less sedating:

A) diphenhydramine (Benadryl)
B) terfenadine (Seldane)
C) about equal

Question # 5 (Multiple Choice) Most uterine selective -- agent of choice for obstetric use among ergot alkaloids

A) ergotamine
B) ergonovine
C) methysergide (Sansert)

Question # 6 (Multiple Answer) Histamine receptor sites-- H1

A) endothelium
B) smooth muscle
C) mast cell
D) gastric mucosa

Question # 7 (Multiple Choice) More likely to be effective in treating an active migraine attack:

A) sumatriptan (Imitrex)
B) methysergide (Sansert)
C) equally effective

Question # 8 (Multiple Choice) Drug treatment for hyperprolactinemia:

A) bromocriptine (Parlodel)
B) pergolide (Permax)
C) both
D) either

Question # 9 (True/False) Long-lasting vasospasm caused by ergotamine overdosage is reversible by alpha antagonists or serotonin antagonists:

A) true
B) false

Question # 10 (Multiple Choice) Ergot alkaloid -- antimigraine specificity mediated by these receptors:

A) adrenergic
B) cholinergic
C) serotonergic
D) dopaminergic

Question # 11 (Multiple Choice) Losartin (Cozaar): higher affinity for

A) AT1 angiotensin receptors
B) AT2 angiotensin receptors

Question # 12 (Multiple Choice) Enzyme catalyzing conversion of angiotensinogen to angiotensin I:

A) serum cholinesterase
B) aspartyl protease
C) dopamine beta-hydroxylase
D) phenylethanolamine N-methyltransferase

Question # 13 (True/False) Migraine -- drug treatment: alternative to ergotamine for acute migraine treatment but not recommended for patients with coronary vascular disease-- sumatriptan (Imitrex)

A) true
B) false

Question # 14 (Multiple Choice) Synthesis site of most circulatory renin:

A) pulmonary
B) liver
C) kidney
D) brain
E) platelet

Question # 15 (True/False) Angiotensin II effects may cause vascular and myocardial hypertrophy

A) true
B) false

Question # 16 (Multiple Choice) CNS effects of ergot alkaloids:

A) activation of pituitary prolactin secretion
B) hallucinogenic effects
C) both
D) either

Question # 17 (Multiple Answer) Mechanism(s) of action for angiotensin II vasopressor response:

A) CNS mediated
B) ANS mediated
C) direct arteriolar smooth muscle contraction

Question # 18 (True/False) Angiotensin II is a more potent vasopressor than norepinephrine

A) true
B) false

Question # 19 (Multiple Choice) Most commonly used drug for continuous migraine prophylaxis:

A) methysergide (Sansert)
B) ergonovine
C) propranolol (Inderal)
D) amitriptyline (Elavil, Endep)
E) valproic acid

Question # 20 (Multiple Choice) Most common acute ergot toxicity:

A) vasospasm
B) retroperitoneal fibroplasia
C) gastrointestinal upset -- e.g. vomiting
D) subendocardial fibrosis

Question # 21 (Multiple Answer) Receptors affected by ergot alkaloids

A) alpha-adrenergic
B) dopamine receptors
C) serotonin receptors

Question # 22 (Multiple Choice) Equal affinity for saralasin and angiotensin II:

A) AT1 -type angiotensin receptor
B) AT2 -type angiotensin receptor

Question # 23 (Multiple Answer) Sites of angiotensin II actions:

A) vascular smooth muscle
B) brain
C) adrenal cortex
D) kidney

Question # 24 (Multiple Choice) Reverses serious ergot alkaloid-mediated vasospastic reactions:

A) nitroglycerin
B) nitroprusside sodium (Nipride)
C) both
D) neither

Question # 25 (True/False) Major plasma kinin: bradykinin

A) true
B) false

Question # 26 (Multiple Answer) Likely to block renin secretion:

A) clonidine (Catapres)
B) isoproterenol
C) methyldopa (Aldomet)
D) metoprolol (Lopressor)

Question # 27 (Multiple Choice) Receptor type mediating urinary retention associated with first-generation H1 antagonists:

A) adrenergic
B) cholinergic
C) serotonergic
D) GABA-ergic

Question # 28 (Multiple Answer) Stimulates renin-angiotensin system:

A) hydralazine (Apresoline)
B) isoproterenol
C) diuretics
D) losartin (Cozaar)

Question # 29 (Multiple Choice) Common side effect of first-generation H1 antagonists:

A) tachycardia
B) pulmonary hypertension
C) cholecystitis
D) sedation
E) intraperitoneal fibroplasia

Question # 30 (Multiple Choice) Fewer drug-drug interactions

A) terfenadine (Seldane)
B) fexofenadine (Allegra)
C) about equal

Question # 31 (Multiple Answer) Associated with ergotamine -- drug treatment for migraine:

A) best results obtained after attack begins
B) ergotamine commonly combined with caffeine; caffeine promotes ergot alkaloid absorption
C) excessive ergotamine may cause long-lasting, severe vasoconstriction

Question # 32 (True/False) Used to control late uterine bleeding,ergot derivatives are given before delivery

A) true
B) false

Question # 33 (Multiple Answer) clinical uses: H2 receptor blockade:

A) peptic ulcer duodenal disease
B) gastric ulcer
C) gastroesophageal reflux disorder (erosive esophagitis)
D) Zollinger-Ellison disease

Question # 34 (Multiple Choice) Angiotensin antagonist(s):

A) losartin (Cozaar)
B) valsartan (Diovan)
C) both
D) neither

Question # 35 (Multiple Choice) Vascular smooth muscle effects --ergotamine:

A) vasodilatation
B) vasoconstriction

Question # 36 (Multiple Choice) Cardiotoxicity in combining terfenadine (Seldane) with ketoconazole (Nizoral),

A) characterized by Q-T (ECG) prolongation
B) may cause ventricular arrhythmias; potentially fatal
C) both
D) either

Question # 37 (Multiple Answer) Effects of angiotensin II on the kidney:

A) renovascular dilation
B) enhanced sodium reabsorption at the proximal tubule
C) renin secretion