Vasoactive Peptides: Questions Set #1

Controls rate of renin released by sensing changes in the rate of sodium or chloride delivery to the distal tubule:
1. juxtaglomerular cells
2. macula densa
3. renal vascular receptor
4. sympathetic nervous system
By classification an aspartyl protease enzyme which catalyzes conversion of angiotensin I from angiotensinogen:
1. peptidyl dipeptidase (converting enzyme)
2. renin
3. trypsin
4. angiotensinase
5. none of the above
Renin secretion: effects of renal denervation --
1. increased renin secretion
2. decreased renin secretion
Effect on renin secretion following decreased delivery of NaCl to macula densa:
1. increased secretion
2. decrease secretion
Effect of angiotensin II on renin secretion:
1. inhibition
2. stimulation
Drug least likely to provoke an increase in renin release:
1. nitroprusside
2. minoxidil
3. phenylephrine
4. isoproterenol
5. prazosin
Angiotensin II action(s) on blood pressure:
1. promotes contraction of arteriolar smooth muscle
2. no central sites of action
3. no effects on the autonomic nervous system
4. promotes reflex bradycardia
5. A & D
Physiological effects of angiotensin II:
1. increases aldosterone biosynthesis
2. increases glucocorticoid synthesis
3. mitogenic for vascular and cardiac muscle cells
4. A & B
5. A, B & C
Transduction pathway for AT1 (angiotensin receptor type I):
1. ion channel
2. inositol triphosphate/diacylglycerol
3. cyclic AMP
4. prostaglandin
5. thromboxane
High affinity for losartin:
1. AT1 receptors
2. AT2 receptors
3. both
4. neither
Blockade of renin secretion:
1. norepinephrine
2. hydralazine
3. isoproterenol
4. clonidine
5. none of the above
Inhibit renin secretion:
1. clonidine
2. methyldopa
3. propranolol
4. A & C
5. A, B & C
Associated with ACE inhibitor action:
1. blockade of substance P degradation
2. angioedema
3. cough
4. reduced renal vascular injury particularly in diabetic patients
5. all the above
Converting enzyme inhibitor(s):
1. remikiren
2. captopril
3. enalapril
4. B & C
5. A, B & C
Potent, competitive antagonist at angiotensin AT1 receptor sites:
1. captopril
2. enalapril
3. losartin
4. remikiren
5. none of the above