More likely to result in rapid induction by a volatile agent:
if the agent is highly blood soluble
if the agent is sparingly blood soluble
Concerning tension, partial pressure and fractional volume
Agent with the highest brain:blood partition coefficient
lowest fat:blood partition coefficient
definition of the time constant used in relating inspired gas fraction (FI) to fresh gas outlet fraction (FGO)
highest FA/FI ratio after about 20 min. of administration
lowest FA/FI ratio after about 20 min. of administration
If the elapsed time is equal to the time constant, what percentage of the theoretical maximal value will be reached?
Total lung capacity in mls (male)
Approximate tidal voluume for normal young adult (mls)
Definition: functional reserve capacity
Factor(s) likely to increase the FA with time:
Assuming a blood:gas partition coefficient of 2.4, what is the percentage of inhalational agent transferred to the blood from the alveolar volume in a single breath hold?
Consider 1 respiratory cycle: initial volatile agent concentration = 3.4% and nitrous oxide concentration is 72%. Assuming 50% nitrous oxide uptake and no uptake of the volatile agent, what is the volatile agent alveolar concentration due to the second gas effect?
lower rate of FA/FI rise
Generally, for volatile anesthetic agents the rate of rise of FA/FI is typically fairly rapid
Cardiac output and rate of FA/FI rise: choose slowest rate of FA/FI rise among these cardiac output values:
More likely to show differences in FA/FI upon concurrent doubling of both ventilation rate and cardiac output