Medical Pharmacology Chapter 20: Neuromuscular Blocking Agents
Neuromuscular Blocking Drugs: Skeletal Muscle Relaxants
Spasmolytic agents
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Increased in tonic stretch reflexes
Increased flexor muscle spasm
Muscle weakness
Clinical conditions associated with spasticity
Cerebral palsy
Multiple sclerosis
Stroke
Mechanisms of clinical spasticity
Reflex arc involvement
Higher center involvement ("upper motor neuron disease") affects descending pathways leading to alpha-motoneuron hyperexcitability
Mechanisms of drug action that diminish spasticity
Alteration in stretch reflex arc
Attenuation of excitation-contraction coupling
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