Medical Pharmacology: Peptic Ulcer Disease

Table of Contents
Overview Classification of peptic ulcers Gastric Physiology Gastric Mucosa-Acid Secretion Oxidative phosphorylation Regulation of Gastric Acid Secretion Gastrin-stimulatory Vagal effects-stimulatory Role of histamine Parietal Cell Membrane Receptors Physiological Stumulants of Gastric Acid Secretion Food Cephalic Gastric Intestinal Physiological Inhibition of Gastric Acid Secretion Factors Somatostatin Effects Role of pepsin in peptic ulcer disease Pathogenic Factors Helicobacter Pylorii H. Pylorii Management: Clinical Efficacy Other Pathogenic Factors Involvement in Carcinogenesis	Drug Treatment Helicobacter pylorii Bismuth Triple Therapy Drawbacks of Triple Therapy Antacids H₂ Receptor Antagonists Anticholinergic Drugs Coating Agents Sucralfate Colloidal Bismuth Prostaglandins Proton Pump Inhibitors Important GI Drugs: Listing Other GI Drugs Gastrokinetic Agents Antacids (used as preoperative medication) Antiemetic Drugs

**Benign Ulcer**

"Benign chronic gastric ulcer: note sharp margins, flat relatively clean ulcer base and folds that radiate from the ulcer margin, location on the lesser curvature in the antrum at the fundopyloric junctional mucosa (precepitous proximal and sloping distal border not clearly seen)." Courtesy of the University of Texas Health Science Center

This Web-based pharmacology and disease-based integrated teaching site is based on reference materials, that are believed reliable and consistent with standards accepted at the time of development. Possibility of human error and on-going research and development in medical sciences do not allow assurance that the information contained herein is in every respect accurate or complete. Users should confirm the information contained herein with other sources. This site should only be considered as a teaching aid for undergraduate and graduate biomedical education and is intended only as a teaching site. Information contained here should not be used for patient management and should not be used as a substitute for consultation with practicing medical professionals. Users of this website should check the product information sheet included in the package of any drug they plan to administer to be certain that the information contained in this site is accurate and that changes have not been made in the recommended dose or in the contraindications for administration. Advertisements that appear on this site are not reviewed for content accuracy and it is the responsibility of users of this website to make individual assessments concerning this information. Medical or other information thus obtained should not be used as a substitute for consultation with practicing medical or scientific or other professionals.