Medical Pharmacology: Gonadal Hormones and Inhibitors

Mechanism responsible for onset of ovarian function of the time of puberty:
1. maturation of neural centers (e.g.,amygdala)
2. maturation of the gonad
3. responsiveness of the pituitary to hypothalamic gonadotropin-releasing hormones
Early consequence(s) of follicle-stimulating hormone and luteinizing hormone release inducing limited estrogen secretion in response:
1. initiation of growth spurt
2. changes in fat distribution
3. breast development
4. A & B
5. A, B & C
At the beginning of each cycle, some vesicular follicles enlarge in response to:
1. human menopausal gonadotropin (hMG)
2. follicle-stimulating hormone (FSH)
3. adrenocorticotropic hormone (ACTH)
4. sex hormone-binding globulin (SHBG)
5. dehydroepiandrosterone (DAG a)
Granulosa cells in the one of several vesicular follicles that begins to develop more rapidly than the others do so under the influence of:
1. sex hormone-binding globulin
2. luteinizing hormone
3. follicle-stimulating hormone
4. corticosteroid-binding globulin (transcortin)
5. aspartate aminotransferase
Estrogen effects on FSH release (at this stage of the cycle):
1. inhibition
2. stimulation
Composition of the ovarian follicle:
1. fluid-filled antrum
2. granulosa cells
3. theca cells
4. all of the above
Peak time of estrogen secretion:
1. early cycle
2. just before midcycle
3. late in cycle
Following follicle rupture, luteinized theca and granulosa cells proliferate, replacing blood in the ruptured follicle, and forming the corpus luteum.
1. true
2. false
have relatively common cause(s) of persistent, chronic ovulatory disturbances:
1. emotional changes
2. environmental changes
3. pituitary prolactinomas
4. A & B
5. A, B & C
Major ovarian secretory product:
1. estrone
2. estriol
3. estradiol
4. all of the above in equal amounts
Produces estrogen during the first part of the menstrual cycle, before ovulation:
1. theca cells in the ovarian follicle
2. granulosa cells in the corpus luteum
3. both
4. neither
Most prolific natural source of estrogenic substances:
1. pregnant mare
2. stallion
3. pregnant woman
Estradiol precursor(s):
1. estrone
2. testosterone
3. both
4. neither
Immediate estrone and testosterone precursor:
1. estriol
2. androstenedione
3. progesterone
4. dehydroepiandrosterone
5. pregnenolone
Example of a steroidal, synthetic compound with estrogenic activity
1. diethylstilbestrol
2. estrone
3. estradiol
4. ethinyl estradiol
5. methallenestril