Medical Pharmacology: Gonadal Hormones and Inhibitors

Useful for initiation of treatment of primary hypogonadism:
1. progesterone
2. androstenedione
3. ethinyl estradiol
4. estriol
5. estrone
Postmenopausal changes:
1. vasomotor
2. genital hypertrophy
3. improved lipid profiles
4. A & B
5. A, B & C
Lipid profile/receptor changes associated with oophorectomy:
1. decrease in plasma cholesterol
2. decrease in LDL receptors
3. increase in LDL serum levels
4. significant increase in HDL
5. significant increase in triglyceride levels
Estrogen therapy: associated with an increase frequency of home
1. migraine headaches
2. cholestasis
3. hypertension
4. nausea
5. all of the above
Factors influencing osteoporosis development
1. calcium intake
2. degree of physical activity
3. smoking
4. A & B
5. A, B & C
Nonsteroidal, synthetic agent with estrogenic activity:
1. estradiol
2. ethinyl estradiol
3. diethylstilbestrol
4. quinestrol
5. estriol
Prolonged, continuous estrogen exposure -- endometrial effects
1. hypoplasia
2. abnormal leading patterns
3. both
4. neither
Estrogens: bone effects --
1. decrease rate of bone resorption
2. stimulates bone formation
3. both
4. neither
Risk factors for osteoporosis:
1. Caucasian
2. thin build
3. smoking
4. family history
5. all the above
Antiestrogenic activity
1. medroxyprogesterone acetate
2. norethindrone
3. L-Norgestrel
4. A & B
5. A, B & C
Progesterone effect(s):
1. dramatically increases protein metabolism
2. inhibits lipoproteins lipase
3. favor fat deposition
4. blunts insulin response to glucose
5. inhibits ketogenesis
Major uses of progestational hormones:
1. hormone replacement
2. hormonal contraception
3. both
4. neither
Progestin(s) without androgenic activity:
1. desogestrel
2. gestodene
3. norgestimate
4. all the above
Most important human progestin:
1. desogestrel
2. dimethisterone
3. progesterone
4. megestrol acetate
5. hydroxyprogesterone
Chronic use of combination hormonal contraceptives on the ovary:
1. minimal follicular development
2. absence of corpora lutea
3. absence of larger follicles
4. absence of stromal edema
5. all of the above