Medical Pharmacology: Gonadal Hormones and Inhibitors

Primarily used to promote ovulation in patients wishing to become pregnant:
1. Danazol (Donocrine)
2. Medroxyprogesterone acetate
3. Clomiphene (Clomid)
4. L-Norgestrel
5. Tamoxifen (Nolvadex)
Considered a severe adverse effect associated with contraceptive agents:
1. breakthrough bleeding
2. changes in serum proteins
3. gastrointestinal disorders
Factor(s) that increase risk of venous thrombosis in patients taking oral contraceptives:
1. decrease in antithrombin III levels
2. increased homocysteine levels
3. injury
4. A & B
5. A, B & C
Considered serious adverse effects associated with contraceptive use:
1. cancer
2. depression
3. myocardial infarction
4. A & B
5. A, B & C
Clinical uses of progestins:
1. hormone replacement
2. treatment of endometriosis
3. treatment of hirsuitism
4. treating premenstrual syndrome
5. all the above
Consequence(s) of chronic combination contraceptive use:
1. enhanced corpora lutea development
2. enhanced follicular development
3. stromal edema
4. larger follicles
5. none of the above
Change(s) in liver function associated with contraceptive hormone administration:
1. altered drug excretion;changes in drug metabolism
2. reduced cholelithiasis
3. facilitated clearance of sulfobromophthalein
4. increased bile flow
5. all of the above
Adjunct hormonal therapy, particularly in estrogen-receptor-positive breast cancer:
1. Medoxyprogesterone acetate
2. Clomiphene (Clomid)
3. Tamoxifen (Nolvadex)
4. Danazol (Donocrine)
5. all of the above
Selective nonsteroidal aromatase inhibitor; maybe useful in treating breast tumors
1. danazol (Donocrine)
2. anastrozole (Arimidex)
3. tamoxifen (Nolvadex)
4. A & B
5. B & C
Contraceptive Contraindications or Cautions:
1. edema
2. asthma
3. migraine
4. A, B & C
5. none of the above