Drugs that act on the immune system.

Example of first-class of hormonal agents noted to have lipolytic properties:
1. cyclosporine
2. prednisone (Deltasone)
3. tacrolimus
4. IFN-alpha
5. thalidomide
Glucocorticoid effects:
1. inhibition of leukotriene production
2. inhibition of prostaglandins
3. increased chemotaxis
4. A & B
5. A, B & C
Effective in lowering incidents of rejection in infectious complications in transplant patients:
1. azathioprine (Imuran)
2. prednisone (Deltasone)
3. antilymphocyte antibodies
4. cyclosporine (Sandimmune, Neoral)
5. all the above
Tests of immunocompetency:-- measurements
1. in vitro IL-2 stimulation of lymphokine activated killer cell production
2. in vitro lymphocyte profilerative responses to mitogens
3. erythropoiesis
4. A & B
5. A, B & C
About two-thirds of children with early diabetic symptoms can discontinue or reduce insulin treatment within about six weeks after starting treatment with this drug:
1. tacrolimus
2. interferon
3. cyclosporine (Sandimmune, Neoral)
4. prednisone (Deltasone) and
5. thalidomide
This immunosuppressant antibiotic commonly approved for use in liver transplantation, is 10 to 100 times more potent than cyclosporine in inhibiting immune responses:
1. interferon-gamma
2. prednisone (Deltasone)
3. tacrolimus (FK 506)
4. A & B
5. A, B & C
Autoimmune (Type II) drug reaction:
1. penicillin
2. sulfonamides
3. iodides
4. phenytoin (Dilantin)
5. hydralazine (Apresoline)
Implicated in initiation of hypersensitivity vasculitis; a Type III vasculitic reaction:
1. sulfonamides
2. penicillin
3. thiouracil
4. anticonvulsants
5. all the above
Blockade of mediator release following exposure of sensitized tissue mast cells or blood basophils to drugs that initiate Type I drug allergic reactions:
1. isoproterenol (Isuprel)
2. antihistamines
3. theophylline
4. A & C
5. A, B & C
Example of immunostimulatory cytokine that may be useful in cancer immunotherapy
1. levamisole
2. BCG
3. IFN-alpha
4. IL-2
5. none of the above
For synthesized for treating parasitic infections, this drug is now FDA approved for clinical use in the treatment of Dukes class C colorectal cancer after surgery:
1. inosiplex
2. thymopoietin
3. levamisole
4. BCG
5. IGIV
Alkylating agent; destroys proliferating lymphoid cells; in low doses -- for effective against autoimmune disorders including systemic lupus erythematosus
1. azathioprine (Imuran)
2. methotrexate
3. cyclophosphamide (Cytoxan)
4. antilymphocyte globulin (ALG)
5. all the above
Cytotoxic agents with immunosuppressive properties:
1. cyclophosphamide (Cytoxan)
2. vincristine (Oncovin)
3. methotrexate
4. cytarabine (ARA-C)
5. all the above
Type 1 immediate hypersensitivity:
1. due to elevated levels of antigen-antibody complexes
2. stems from cross-linking of membrane-bound IgE on blood basophils or tissue mast cells by antigen
3. follows from formation of antigen- antibody complexes between foreign antigen and IgM or IgG immunoglobulins
4. tissue damage due to influx of antigen-nonspecific inflammatory cells (macrophages and neutrophils)
Autoimmune disorder: associated with antibodies made against self DNA, red blood cells, histones, platelets
1. rheumatoid arthritis
2. systemic lupus erythematosus
3. insulin dependent diabetes