Sites of action of immunosuppresive drugs: practice questions

Agent acts directly at site 6 to diminish tissue injury: (see figure)
1. tacrolimus
2. cyclosporine (Sandimmune, Neoral)
3. prednisone (Deltasone)
4. dactinomycin (Cosmegen)
5. methotrexate
Act(s) at site 2, reducing proliferation (see figure)
1. prednisone (Deltasone)
2. tacrolimus
3. azathioprine (Imuran)
4. A & B
5. A, B & C
Inhibit(s) at differentiation/synthesis step (see figure):
1. prednisone (Deltasone)
2. cyclophosphamide (Cytoxan)
3. dactinomycin (Cosmegen)
4. methotrexate
5. azathioprine (Imuran)
Acts at three sites: antigen recognition site, proliferation step, and differentiation/synthesis steps: (see figure)
1. prednisone (Deltasone)
2. antilymphocyte globulin & monoclonal anti-T cell antibodies
3. RHo(D) immune globulin
4. cyclophosphamide (Cytoxan)
5. all of the above
Anti-profilerative site of action:
1. antilymphocyte globulin & monoclonal anti-T cell antibodies
2. dactinomycin (Cosmegen)
3. methotrexate
4. azathioprine (Imuran)
5. all the above
Acts at antigen recognition site: (see figure)
1. prednisone (Deltasone)
2. tacrolimus
3. azathioprine (Imuran)
4. RHo(D) immune globulin
5. cyclophosphamide (Cytoxan)