Medical Pharmacology Chapter 28: Physiology and Pharmacology: Adrenocorticosteroids / Adrenocortical Antagonists
Adrenocorticosteroids and Adrenocortical Antagonists
Natural adrenocortical hormones:
Steroid molecules are synthesized and released by the adrenal cortex.
Diagnosis of adrenal function
Treatment of adrenal function disorders
Treatment of inflammatory/immunological disorders (at higher doses)
Control over adrenocorticosteroid secretion
Pituitary corticotropin (ACTH) release
Angiotensin modulation of aldosterone secretion
Quantitatively -- DHEA
DHEA and androstenedione: very weak androgens
Small amount of testosterone, secreted by the adrenals, maybe more important
Adrenal androgens: testosterone and androstenedione may be converted to estrone by non-endocrine tissue:
Major endogenous estrogen source in women after menopause.
Goldfien, A.,Adrenocorticosteroids and Adrenocortical Antagonists, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 635-650.
Williams, G. H and Dluhy, R. G. , Diseases of the Adrenal Cortex, In Harrison's Principles of Internal Medicine 14th edition, (Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S. and Kasper, D.L., eds) McGraw-Hill, Inc (Health Professions Division), 1998, pp 2035-2056
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