Anesthesia Practice Questions: Antiarrhythmic Drugs

Mexilitine (Mexitil) is a member of this class of antiarrhythmic drugs.
1. Sodium channel blockers
2. Potassium channel blockers
3. Chloride channel blockers
4. Calcium channel blockers
Mexilitine similar to its chemically related agent lidocaine may only be administered by IV due to high first pass metabolism.
1. True
2. False
Electrophysiological characteristics of mexilitine is probably most similar to this agent.
1. Quinidine
2. Diltiazem
3. Lidocaine
4. Disopyramide
Mexilitine has been approved for treating ventricular arrhythmias.
1. True
2. False
Mexilitine when combined with sotalol or quinidine may exhibit both increased efficacy and reduced adverse effects.
1. True
2. False
Prominent, major dose-related adverse effects associated with mexiletine administration include which one(s) of the following?
1. Nausea
2. Tremor
3. Both
4. Neither
Both phenytoin (an anticonvulsant drug) and mexilitine exhibit comparable electrophysiological effects.
1. True
2. False
Prominent side effects associated with mexiletine administration include which one(s) of the following?
1. Tremor
2. Blurred vision
3. Lethargy
4. A & C
5. A & B
6. A, B & C
Noteworthy off-label use(s) of mexiletine:
1. Management of renal dysfunction
2. Treatment of pulmonary fibrosis
3. Treatment of pain secondary to diabetic neuropathy
4. Management of chronic fatigue syndrome
5. All of the above
Mexilitine exhibits elimination half-life in the range of 8-20 hours, allowing for drug administration typically at this frequency
1. Once daily
2. 2-3 times daily
3. Four times daily