Anesthesia Pharmacology Practice Questions: Antiarrhythmic Drugs

Flecanide (Tambocor) is classified as a principal blocker of which one(s) of the following cardiac ion channels?
1. Sodium
2. Potassium
3. Calcium
4. Chloride
5. A & B
6. A & C
7. A, B & C
Flecanide, a blocker of some potassium channels, has the following effect(s):
1. Prolongation of action potential duration
2. Increased duration of the QT interval on ECG
3. Both
4. Neither
Flecanide, like quinidine, exhibits antimuscarinic properties.
1. True
2. False
Choose the following correct statement(s) concerning flecanide.
1. Flecanide is approved for patients with atrial fibrillation
2. Flecanide in a major clinical study study was shown to elevate mortality in patients recovering from myocardial infarction.
3. Both
4. Neither
Choose the correct statement(s) concerning flecanide.
1. Flecanide administration disproportionately prolongs, at fast rates, the cardiac action potential.
2. Flecanide increases PR, QRS, and QT intervals at normal heart rates.
3. Both
4. Neither
The most common noncardiac adverse effect associated with flecanide is blurred vision, dose-related effect.
1. True
2. False
The most serious adverse effect associated with flecanide administration would be the induction or worsening of potentially lethal arrhythmias.
1. True
2. False
Flecanide elimination occurs by which one(s) oof the following routes?
1. Renal excretion of unchanged flecanide.
2. Liver metabolism mediated by CYP2D6 of flecanide to be an active metabolites.
3. Both
4. Neither
Flecanide is considered quite effective in reducing the frequency of premature ventricular contractions.
1. True
2. False
Rarely, flecanide is associated with torsades de pointes.
1. True
2. False