Anesthesia Pharmacology: Antianginal Drugs

• Angina: Treatment Objectives and Approaches: Treatment objectives include both acute management and prevention of anginal episodes:

  • Acute Management

    • These agents cause systemic venodilation and therefore reduce myocardial wall tension and oxygen requirements

    • Nitrates dilate epicardial coronary capacitance vessels thereby increasing blood flow in collateral vessels.

    • Although other nitrates may be used in management of angina, other preparations are less effective in acute management.

• Chronic Management

  • Medical management is individualized for each patient, including patient education and counciling to assist in reduction of risks of coronary heart disease.

  • Risk management includes:

    • Optimal treatment or elimination of co-existing illness such as diabetes mellitus and hypertension.

    • Dietary and drug therapy of dyslipidemias

    • Smoking cessation

    • Adaptation of activities, such as increasing the amount of time needed to accomplish a task which if performed more rapidly could induce angina.

  •  

    "Acute Coronary Syndromes"

    Attribution: Eagle K Acute Coronary Syndromes https://www.youtube.com/watch?v=dFXGbiIJgh8  (9/2012) openmichigan Youtube Channel:  https://www.youtube.com/channel/UCBxvSOKtSNZFU7z1KbcZqPg

  •  

    "Treatment of Acute Coronary Syndrome (ACS)"

    Attribution:  Treatment of Acute Coronary Syndrome (ACS) https://www.youtube.com/watch?v=rEqw3AK-M_g  mdconversation Youtube Channel:  https://www.youtube.com/channel/UCy0XRMQjQmN9cu-hryXJFtA

Selwyn, A.P. and Braunwald, E Ischemic Heart Disease in Harrison's Principles of Internal Medicine (Isselbacher et al., eds) McGraw-Hill, Inc., New York, 1994, p 1081-2.

 

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