β-adrenoceptor antagonists are beneficial in reducing:
Frequency of anginal episodes
Severity of exertional angina attacks
Not effective in variant angina (may even worsen condition)
Effective antianginal drugs:
Antianginal effects of β-blockers are due to:
Decreased heart rate
Decreased blood pressure during exercise (reduced
β-adrenoceptor antagonists may be used in combination with
nitrates and calcium channel blockers in select patients
In patients with significantly reduced left ventricular
function and limited myocardial reserve, β-receptor
blockade may precipitate heart failure by blocking essential
Note, however, that beta-receptor
antagonists are important drugs in management of congestive
heart failure in many patients.
Testing Propranolol: A non-selective beta blocker"
James Black: "The late Scottish pharmacologist Sir James W. Black
(1924-2012) revolutionized medical treatment of hypertension and
angina with his invention of propranolol, the first ever beta
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