Anesthesia Pharmacology Practice Questions: Coronary Artery Disease and Angina

Choose which one(s) of the following statements concerning ranolazine is/are correct.
1. Ranolazine induced QT interval prolongation with associated clinically significant arrhythmias represent an important adverse effect. Ranolazine when combined with amlodipine, atenolol, or diltiazem increased time to anginal onset and improve exercise performance.
2. Ranolazine is classified as a selective late sodium influx inhibitor.
3. A & B
4. A & C
5. B & C
6. A, B & C
Ranolazine exhibits important drug interactions and therefore they not be appropriate in patients receiving for example quinolones or azole antifungal medications as well as certain other drugs.
1. True
2. False
Ranolazine is most appropriate when administered to patients with continuing anginal symptoms even while receiving maximal medical treatment or in the case in which the patient is intolerant of other antianginal medications due to adverse reactions.
1. True
2. False
Calcium channel blockade (calcium entry blockade) promote relaxation of vascular smooth muscle, particularly in arterial vascular beds.
1. True
2. False
This drug is an example of a benzothiapine-type calcium channel blocker.
1. Verapamil
2. Nifedipine
3. Diltiazem
4. None of the above
Example(s) of dihydropyridine-type calcium channel blockers include(s):
1. Amlodipine
2. Felodipine
3. Isradipine
4. Nimodipine
5. All of the above
Choose (the) statement(s) concerning calcium and cardiac and vascular smooth muscle cells.
1. Increasing concentrations of cytosolic calcium is associated with enhanced cardiac and vascular smooth muscle cellular contraction.
2. Calcium channel antagonist effects result from binding to the L-type calcium channel, decreasing calcium movement through the channel.
3. Both
4. Neither
The polarization of vascular smooth muscle cells depends mainly on sodium influx.
1. True
2. False
Which one(s) of the following statements is/are correct concerning hemodynamic effects of calcium channel blockers?
1. Clinically used calcium channel blockers reduce coronary vascular resistance.
2. Dihydropyridine-type calcium channel blockers exhibit less vasodilation compared to verapamil or diltiazem.
3. Nifedipine, for example, exerts a selective dilation on venous capacitance vessels.
4. All of the above statements are true
This dihydropyridine-type L-type calcium channel antagonist exhibits a very fast onset and offset of action, with a t1/2 of about 2 min.
1. Nimodipine
2. Clevidipine
3. Verapamil
4. Amlodipine