Anesthesia Pharmacology:  Neuromuscular Blocking Agents and Muscle Relaxants

Previous Page Page Forward

Section Table of Contents

Site Table of Contents

Non-depolarizing Blocking Drugs

 

Table of Contents

Factors which alter patient responses to nondepolarizing agents

Drugs

Diuretics

Ganglionic blocking agents

Magnesium

Aminoglycoside antibiotics

Local anesthetics

Volatile anesthetics

Antiarrhythmic agents

Lithium

 

Other Factors Influencing Responses to Nondepolarizing Agents

Hypotension

Altered serum potassium

Adrenocortical abnormality

Burned injury

Allergic reactions

Abnormal acid-base balance

 

Gender may also influence duration of action;  combinations of nondepolarizing neuromuscular-blocking agents may result in different effects than agents used separately

Some aminoglycosides

  •  Streptomycin

  •  Gentamicin (Garamycin)

  •  Tobramycin (Nebcin)

  •  Amikacin (Amikin)

  •  Kanamycin (Kantrex)and Neomycin

  •  Spectinomycin (Trobicin)

Stoelting, R.K., "Neuromuscular-Blocking Drugs", in Pharmacology and Physiology in Anesthetic Practice, Lippincott-Raven Publishers, 1999, pp 182-219; White, P. F. "Anesthesia Drug Manual", W.B. Saunders Company, 1996; Miller, R.D., Skeletal Muscle Relaxants, in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 434-449.

 

Previous Page Page Forward

Section Table of Contents

Site Table of Contents