Anesthesia
Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
1 / 10
Among the proton pump inhibitors, this agent exhibits a relatively more rapid onset of gastric acid inhibition compared other oral preparations.
Lansoprazole
Dexlansoprazole
Rabeprazole
Omeprazole
This proton pump inhibitor is most likely associated with the shortest half-life.
Rabeprazole
Pantoprazole
Omeprazole
Lansoprazole
Proton pump inhibitors:
Weak bases
Weak acids
The bioavailability of proton pump inhibitors is enhanced by food and therefore should be administered following a meal.
True
False
Concerning inhibition of proton pumps by omeprazole and related agents:
These agents are effective inhibitors only when the proton pump is actively secreting acid.
A small fraction, about 10%, proton pumps secrete acid actively during fasting.
Both
Neither
Following proton pump discontinuation, as long as 3-4 days is required before normal acid secretion is reinitiated.
True
False
Proton pump inhibitors exhibit very limited renal clearance and exhibit first-pass as well as subsequent liver metabolism.
True
False
Due to the short half-life of a single injection of one of the intravenous formulations of pantoprazole and esomeprazole, maximal proton pump inhibition during the first 1-2 days of treatment requires either repeated bolus injections or continuous infusion.
True
False
Pharmacokinetic characteristic(s) of proton pump inhibitors:
Generally short serum half-life
Both concentrated in activated close to their intended site of action.
Relatively long duration of action.
A & B
B & C
A & C
A, B & C
Proton pump inhibitors represent the most efficacious drugs in the following therapeutic setting(s).
Reflux disease (GERD) effects on the esophagus including Barrett's esophagus and peptic stricture)
