Medical Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
More commonly used in acute peptic ulcer treatment
H2 Receptor blockers
Proton pump inhibitors
Both drug classes equally used
H2 receptor blockers support ulcer healing in patients with uncomplicated duodenal and gastric ulcers in the context of nocturnal acid release suppression.
True
False
Concerning peptic ulcer healing when the ulcer is a consequence of aspirin or other NSAIDs:
The NSAID should be discontinued.
If the NSAID must be continued due to clinical circumstances despite the presence of active ulceration, the drug intervention of choice would be an H2 blocker
Both
neither
Since proton pump inhibitors utilize the hepatic microsomal cytochrome P450 drug metabolizing system:
Proton pump inhibitor administration may influence warfarin metabolism.
Proton pump inhibitor administration can influence diazepam metabolism.
Both
Neither
Chronic proton pump inhibitor drug administration may be associated with:
Increase likelihood of hospital-acquired pneumonia
Community-acquired
Clostridium difficile
Both
Neither
Chronic proton pump inhibitor drug administration may be associated with:
Increased likelihood of bacterial peritonitis in ascites patients
Increased risk of bone fracture
Both
Neither
Principal use(s) of proton pump inhibitors in the clinical setting:
Treatment of gastroesophageal reflux disease (GERD)
Promotion of gastric and duodenal ulcer healing
Both
Either
Proton pump inhibitor dose rejection is typically required in patients with renal insufficiency or mild-to-moderate hepatic disease.
