Anesthesia
Pharmacology: Gastrointestinal Pharmacology Practice Questions
Choose the correct answer for each question.
Eluxadoline (Reversi):
- Opiate agonist (mu receptor)
- Slower colonic transit; increased fecal fluid absorption.
- Both
- Neither
Eluxadoline: approved for management of diarrhea-predominant irritable bowel syndrome (IBS).
- True
- False
Contraindication(s) for eluxadoline administration:
- In patients with known sphincter of Oddi disease.
- In patients with pancreatitis history or alcoholism.
- Both
- Neither
Diphenoxylate or difenoxin: CNS activity results in abuse potential or addiction.
- True
- False
Diphenoxylate or difenoxin when combined with atropine and given at high doses anticholinergic effects can result in:
- Nausea
- Blurred vision
- Both
- Either
Opioids used for diarrhea:
- Codeine
- Paragoric
- Both
- Neither
Enkephalins, endogenous opioids, can be administered to manage acute diarrhea.
- True
- False
Enkephalins and management of diarrhea:
- These agents reduce intestinal secretion without influencing intestinal motility.
- Racecadotril (acetorphan) is in enkephalin prodrug converted to thiorphan that can produce an antidiarrheal effect.
- Both
- Neither
The racecadotril metabolite thiorphan:
- Increases endogenous enkephalin effects on the mu opioid receptor in the G.I. tract.
- Antidiarrheal effect is due to anti-secretory properties.
- Both
- Neither
Antidiarrheal effects of thiorphan occurs as a result of reducing peripheral enkephalin degradation.
- True
- False