Anesthesia Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Histamine H₁ receptor blockers:
1. Effective in managing postoperative emesis
2. Useful for motion sickness
3. Both
4. Neither
Site(s) of action for histamine H₁-type receptor antagonists with respect to activity against motion sickness and postoperative emesis.
1. Brainstem
2. Vestibular afferents
3. Both
4. Neither
Which one(s) of the following drugs is/are classified as a histamine H₁ receptor blocker(s)?
1. Terfenadine (Seldane, Teldane, Triludan)
2. Cyclizine (Marezine, Valoid and others)
3. Diphenhydramine
4. A & B
5. B & C
6. A & C
7. A, B & C
Sedation is an expectable, common side effect of histamine H₁ receptor antagonists.
1. True
2. False
The most frequently used antimuscarinic drug for motion sickness:
1. Atropine
2. Scopolamine
3. Benztropine (Cogentin)
Scopolamine:
1. Some effectiveness in postoperative nausea and vomiting management.
2. Primary use in prevention and treatment of motion sickness.
3. Both
4. Neither
Side effects associated with anticholinergic drugs include(s):
1. Drowsiness
2. Effects on vision
3. Dry mouth (Xerostomia)
4. A & B
5. B & C
6. A & C
7. A, B & C
Meclizine (Bonine and others):
1. Limited anticholinergic effects (less sedation than other agents)
2. Used in management of vertigo secondary to labyrinth abnormality.
3. Both
4. Neither
Scopolamine (Hyoscine):
1. Low incidence of anticholinergic effects of given orally.
2. Best tolerance of the drug is associated with transdermal patch route of administration.
3. Both
4. Neither
Lorazepam or diazepam (benzodiazepines) decreases the likelihood of "anticipatory vomiting" (vomiting associated with anxiety) e.g. before beginning a chemotherapy session.
1. True
2. False

Anesthesia Pharmacology: Gastrointestinal Pharmacology Practice Questions