Emetogenic chemotherapy is associated with both an acute phase and a delayed phase. Agents belonging to this class of drugs are particularly effective for managing the acute phase.

Emetogenic chemotherapy is associated with both an acute phase and a delayed phase. Agents belonging to this class of drugs are particularly effective for managing the delayed phase.

NK₁ receptors represent receptors for the neuropeptide substance P.

Example(s) of (an) NK₁ receptor antagonist(s):

Rolapitant exhibits an unusually long t_1/2 (about four days).

Administration, plasma protein binding and metabolism of aprepitant:

Due to the possibility of life-threatening ECG QT prolongation, aprepitant should not be administered to patients receiving:

Example(s) of drug(s) metabolized by CYP3A4 and thus subject to dose adjustment in individuals receiving aprepitant (CYP3A4 substrate)

Rolapitant:

A relatively recent approved drug combination involves netupitant along with palonosetron.