Anesthesia Pharmacology Chapter 27: Gastrointestinal Pharmacology Practice Questions

Dronabinol (Marinol; Syndros):
1. Dronabinol is the major psychoactive component of marijuana (δ⁹-tetrahydrocannabinol (THC)).
2. Following oral administration, this agent is completely absorbed.
3. Dronabinol undergoes substantial first-pass liver metabolism.
4. A & B
5. B & C
6. A & C
7. A, B & C
Dronabinol, due to alternative drugs being more effective, is rarely used for prevention of nausea and vomiting secondary to chemotherapy.
1. True
2. False
Combining dronabinol with phenothiazine drugs:
1. Synergistic antiemetic effects.
2. Increased adverse effects associated with each drug.
3. Both
4. Neither
Adverse effect category/categories:
1. CNS effects
2. Autonomic effects
3. Both
4. Neither
Nabilone (Cesamet): recently approved in the USA tetrahydrocannabinol derivative.
1. True
2. False
Autonomic side effect(s) associated with dronabinol administration:
1. Hypertension
2. Conjunctival infection
3. Bradycardia
4. A & B
5. B & C
6. A & C
7. A, B & C
Dronabinol: mechanism of action: stimulation of the CB1 cannabinoid receptor subtype localized:
1. Around in in the chemoreceptor trigger zone (CTC)
2. Associated with the emetic center
3. Both
4. Neither
Following single dosing and given first-pass metabolism, systemic availability:
1. 5%
2. 10%-20%
3. 40%
4. 50%-60%
Dronabinol administration is associated with a large volume of distribution. This large volume of distribution suggests:
1. Following a single dose of dronabinol, metabolites are likely undetectable after 1-2 days.
2. Following a single dose of dronabinol, metabolites are likely detectable for a few weeks.
Under circumstances in which other antiemetic drugs are not efficacious a given patient, dronabinol may be a useful preventative agent in individuals receiving cancer chemotherapy.
1. True
2. False
Nabilone is an appropriate prophylactic agent for patients undergoing chemotherapy if other antiemetic drugs are not working.
1. True
2. False
Adverse effects associated with nabilone administration are surprisingly different from that observed with dronabinol.
1. True
2. False

Anesthesia Pharmacology: Gastrointestinal Pharmacology Practice Questions