Anesthesia Pharmacology: Histamine and Histamine Antagonist Practice Questions

H2 Blocker most likely to inhibit P450 drug metabolizing system:
1. ranitidine (Zantac)
2. cimetidine (Tagamet)
3. famotidine (Pepcid)
4. nizatidine (Axid)
5. all inhibit equally
H2 blocker most likely to cause gynecomastia:
1. ranitidine (Zantac)
2. famotidine (Pepcid)
3. cimetidine (Tagamet)
4. nizatidine (Axid)
5. clonidine (Catapres)
Most likely to be effective and used in current therapy for duodenal ulcer
1. atropine
2. scopolamine
3. famotidine (Pepcid)
4. cyproheptadine (Periactin)
5. diphenhydramine (Benadryl)
Example of second-generation antihistamine:
1. cyclizine (Marezine)
2. diphenhydramine (Benadryl)
3. astemizole (Hismanal)
4. cyproheptadine (Periactin)
5. doxylamine
Antihistaminic most likely to exhibit anticholinergic activity:
1. dimenhydrinate (Dramamine)
2. astemizole (Hismanal)
3. fexofenadine (Allegra)
4. terfenadine (Seldane)
5. loratidine (Claritin)
The most important pathophysiologic mechanism of mast cell and basophil histamine release:
1. chemical (i.e. morphine)
2. mechanical cell injury
3. immunologic
Non-neuronal site(s) of histamine storage and release:
1. basophils
2. enterochromaffin-like cells
3. mast cells
4. A & C
5. A, B & C
Histamine aerosol: effects on pulmonary function --
1. bronchoconstriction
2. bronchodilation