H2-histamine receptor antagonists were effective in managing acid-peptic disease because H2 receptor blockers inhibited the proton pump.

Site of action for H2 receptor antagonists with respect to acid production inhibition:

Choose the correct statement(s) concerning H2 receptor antagonists:

Which one(s) of the following agents are classified as H2 histamine receptor antagonists?

Which one(s) is/are (an) example(s) of (an) H2 histamine receptor antagonist(s)?

Choose the most potent H2-histamine receptor antagonists compared to cimetidine (least potent):

Cimetidine, famotidine, and ranitidine undergo first pass, liver metabolism parent drug enters the systemic circulation.

The bioavailability of ranitidine is estimated at about 50% of the oral dose..

This age to-histamine receptor blocker, compared to the others listed, exhibit minimal first-pass hepatic metabolism.

H2-histamine antagonists dosing may require reduction in patients exhibiting either renal (moderate to severe) or liver (severe) insufficiency.