Gastrointestinal parietal cells express which one(s) of the following receptors, the activation of which results in acid secretion?

Enterochromaffin-like (ECL) cells stimulate histamine release following activation of this/these receptor(s):

Vagal postganglionic nerve-mediated acetylcholine release and subsequent acetylcholine binding to parietal cell receptors cause an increase in cytosolic calcium thus activating protein kinases which cause increased acid secretion utilizing a proton pump, the H⁺/K⁺-ATPase.

Most (greater than 90%) of peptic ulcers are due to:

Administration of H2-histamine receptor blockers results in noncompetitive inhibition at parietal cell H2-histamine receptors and suppress only basal, not meal-stimulated acid secretion.

Both antacids and H2-histamine receptor antagonists are helpful in managing infrequent heartburn/dyspepsia.

Clinical uses of H2-histamine receptor blockers include/includes:

Effective agent(s) in decreasing the likelihood of clinically important bleeding in stress-related gastritis.

For patients at risk of bleeding from stress-related gastritis and absent a nasoenteric tube, which one of the following options appear preferable

Administration of this agent is less likely to result in cytochrome P450-related drug-drug interaction