Anesthesia Pharmacology Practice Questions: Bradykinin Pharmacology

Kinins:
1. Formed by kallikreins acting on kininogens..
2. Kinins are structurally peptides
3. Kinins exert vasodilatory actions
4. A & B
5. A & C
6. A, B & C
The renin-angiotensin system and the kallikrein-kinin system have some common features.
1. True
2. False
Kallikreins in terms of their enzyme classification:
1. Tyrosine kinases
2. Peptidases
3. Serine proteases
4. Hydroxylase
Locations where kallikreins may be found:
1. Plasma
2. Organs
3. Both
4. Neither
Plasma prekallikrein is activated by the blood factor XII, a coagulation factor (FXIIa), through proteolytic cleavage.
1. True
2. False
Kininogens:
1. Kallikreins substrate
2. Kinin precursor
3. Both
4. Neither
Concerning plasma kininogens:
1. Two plasma forms
2. The LMW form is the form that can cross capillary walls. This form becomes a substrate for kallikreins in the tissues.
3. Both
4. Neither
Major kinin(s) form(s) in humans:
1. Lys-bradykinin (kallidin)
2. Bradykinin
3. Both
4. Either
Bradykinin by means of plasma kallikrein is released from HMW kininogen.
1. True
2. False
Kallidin is released from low-molecular-weight (LMW) by tissue kallikrein.
1. True
2. False