Anesthesia Pharmacology Practice Questions: Bradykinin Pharmacology

Kinin metabolism:
1. Metabolized by nonspecific exopeptidases
2. Metabolized by endopeptidases
3. Both
4. Neither
Bradykinin is nearly completely inactivated by hydrolysis during the singular pulmonary vascular bed passage.
1. True
2. False
Plasma kininase(s) [endopeptidases and exopeptidases] characteristic(s):
1. Kininase I: Hepatic synthesis
2. Kininase II: localized in vascular endothelial cells in plasma
3. Both
4. Neither
With respect to mediation of arteriolar dilation, histamine is about 10 times more potent compared to kinins.
1. True
2. False
Vascular bed(s) that exhibit vasodilation due to kinins:
1. Skeletal muscle
2. Kidney
3. Both
4. Neither
Probable mechanism associated with kinin-related arteriolar dilation:Kinin effects dependent on promoting nitric oxide release
1. True
2. False
Choose the correct statement(s) concerning bradykinin-induced bronchoconstriction:
1. This action is inhibited by anticholinergic drugs
2. This action is inhibited by antihistamines
3. This action is inhibited by cyclooxygenase inhibitors
4. All of the above
Kinins and inflammatory reactions:
1. Kinins reduce microcirculatory permeability
2. Kinins induce edema
3. Both
4. Neither
Kinins are likely involved in both asthma and rhinitis.
1. True
2. False
Kinins and pain: choose the correct statement/statements:
1. Kinins are pain-inducing agents.
2. Kinins activate primary sensitive neurons.
3. Kinins induce release of neuropeptides involved in pain such as substance P
4. A & B
5. A & C
6. A, B & C