Anesthesia Pharmacology Chapter 25: Pulmonary Pharmacology Practice Questions

Leukotriene pathway inhibitor acting by enzyme inhibition:
1. Montelukast
2. Zileuton
3. Zafirlukast
For inducing and as maintenancein management of asthma leukotriene pathways inhibitors appear at least as effective for more effective than inhaled corticosteroid treatment.
1. True
2. False
Possible advantage/advantages of leukotriene pathway inhibitors compared to inhaled corticosteroids in management of asthma in children
1. Sometimes parents prefer leukotriene pathway inhibitors (zileuton,zafirlukast, montelukast) compared to inhale steroids due to concerns about corticosteroid toxicities.
2. Oral administration of leukotriene pathway inhibitors may be better tolerated i.e. easier then young children's acceptance of aerosol inhalation.
3. Both
4. Neither
The leukotriene receptor blocker montelukast has been approved in children as young as one year of age.
1. True
2. False
Particularly effective role for leukotriene pathway inhibitors:aspirin-worsened respiratory disease (about 7% of asthma patients.)
1. True
2. False
Characteristics of aspirin-exacerbated respiratory disease (AERD):
1. Asthma features
2. Rhinosinusitis with nasal polyps
3. Both
4. Neither
AERD (aspirin-exacerbated respiratory disease) is likely due to prostaglandin synthase (cyclooxygenase) inhibition.
1. True
2. False
Most often prescribed of the leukotriene pathway inhibitors:
1. Zileuton
2. Montelukast
3. Zafirlukast
Anti-leukotriene medications:
1. Effective in preventing exercise-induced asthma
2. Principal mechanism of action is anti-bronchoconstriction
3. Both
4. Neither
Zafirlukast, zileuton and montelukast:
1. Associated with hepatic dysfunction (rare)
2. Zafirlukast and montelukast may be associated with Churg-Strauss syndrome.
3. Both
4. Neither