Anesthesia Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Adverse effect(s) associated with carbonic anhydrase inhibitors:
1. Bone marrow depression
2. Skin toxicity
3. Allergic reactions
4. Sulfonamide-like renal pathology
5. A & B
6. B & C
7. A & C
8. A, B & C
9. A, B, C & D
Choose the correct answer(s) concerning adverse effects associated with administration of carbonic anhydrase inhibitors:
1. Occurring as a result of urinary alkalinization
2. Metabolic acidosis
3. Both
4. Neither
Adverse effect(s) due to carbonic anhydrase administration:
1. Calculus (stone) formation along with ureteral colic
2. Causing a worsening of respiratory acidosis or metabolic acidosis
3. Both
4. Neither
Adverse effect(s) due to carbonic anhydrase administration:
1. Decrease of urinary excretion of weak organic base molecules.
2. Increase of renal generated ammonia from urine to the systemic circulation.
3. Both
4. Neither
Their carbonic anhydrase inhibitor acetazolamide may be helpful under certain circumstances and correcting metabolic alkalosis.
1. True
2. False
Acute mountain sickness and carbonic anhydrase inhibitors:
1. Serious cases may result in pulmonary or cerebral edema.
2. In more severe cases, acetazolamide may increase ventilation and reduced mountain sickness symptoms.
3. Both
4. Neither
Use(s) of carbonic anhydrase inhibitors
1. Management of CSF leakage (cerebrospinal fluid leakage)
2. Increasing urinary phosphate excretion during severe hyperphosphatemia
3. Both
4. Neither
Carbonic anhydrase administration may cause hyperchloremic metabolic alkalosis which can persist during the duration of drug treatment.
1. True
2. False
carbonic anhydrase administration can lead to phosphorus wasting as well as potassium wasting.
1. True
2. False
Toxicity/toxicities of acetazolamide:
1. Drowsiness
2. Parasthesias
3. Both
4. Neither