Anesthesia Pharmacology Chapter 26: Renal Pharmacology Pharmacology Practice Questions

Characteristic(s) of osmotic diuretics:
1. Secreted, not filtered at the glomerulus
2. Significant reabsorption by the renal tubule
3. Both
4. Neither
Mannitol and glycerin (available in the US) are basically pharmacologically inert substances.
1. True
2. False
Primary site of action of osmotic diuretics.
1. Proximal tubule
2. Loop of Henle
3. Neither
Which one(s) of the following is/are correct concerning osmotic diuretics?
1. These agents limited water osmosis to the interstitial space
2. Net Na⁺ reabsorption ceases as a result of osmotic diuretic mediated decrease in luminal Na⁺ concentration.
3. Both
4. Neither
Osmotic diuretic effect/effects:
1. Reduce blood viscosity
2. Decrease renin release
3. Both
4. Neither
Administration of osmotic diuretics has the effect of decreasing extracellular fluid volume.
1. True
2. False
Clinical use(s) of mannitol:
1. Rapid removal of renal toxins
2. Decrease intracranial pressure
3. Both
4. Neither
Mannitol is extensively metabolized and undergo significant first-pass elimination.
1. True
2. False
Mannitol counters the action of antidiuretic hormone (ADH) in the collecting tubule.
1. True
2. False
Mannitol administration: which one of the following actions is the greater?
1. Natriuresis
2. Water diuresis