Anesthesia Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Most effective of the currently available diuretic drugs:
1. Thiazide diuretics
2. Loop diuretics
3. Carbonic anhydrase inhibitors
4. Osmotic diuretics (e.g. mannitol)
This diuretic is described as a phenoxyacetic acid derivative.
1. Torsemide
2. Ethacrynic acid
3. Both
4. Neither
Principal site of action of bumetanide:
1. Collecting duct
2. Proximal tubule
3. Thick ascending loop of Henle
4. Distal tubule
Which drug in the following list is NOT a sulfonylurea or an agent containing a sulfonamide moiety?
1. Furosemide (Lasix)
2. Bumetanide (Bumex)
3. Torsemide (Demadex)
4. Ethacrynic acid (Edecrin)
Loop diuretics are also called "high-ceiling diuretics."
1. True
2. False
Which one(s) of the following is/are correct?
1. Furosemide is available as an oral and injectable agent
2. .Bumetanide is available as an oral and injectable formulation.
3. True
4. False
Ethacrynate sodium is available in injectable form.
1. True
2. False
Concerning the pharmacokinetics of loop diuretics, choose which one(s) of the following statements is/are correct.
1. Loop diuretics are eliminated by glomerular filtration and tubular secretion
2. Loop diuretics are typically absorbed rapidly.
3. Both
4. Neither
Concerning the loop diuretic torsemide:
1. Oral torsemide is absorbed more rapidly compared to furosemide.
2. Compared to torsemide, bumetanide pharmacokinetics appear similar; however, bumetanide is notably more potent in its activity as a loop diuretic.
3. Both
4. Neither
Longer duration of action:
1. Torsemide
2. Furosemide
3. Neither, both agents have the same duration of action