Anesthesia Pharmacology Chapter 26: Renal Pharmacology Practice Questions

Furosemide effect/effects:
1. Increasing systemic venous capacitance (acute)
2. Reduce left ventricular filling pressure.
3. Both
4. Neither
Loop diuretics in high doses can induce ototoxicity, especially in individuals with pre-existing hearing difficulty.
1. True
2. False
Associated with loop diuretic-induced volume depletion:
1. Sympathetic nervous system activation (reflex effect)
2. Activation of intrarenal baroreceptors
3. Both
4. Neither
Concerning loop diuretics, which one(s) of the following is/are correct?
1. Loop diuretics are delivered to tubules mainly by filtration.
2. Loop diuretics are secreted and interact with the transport mechanisms associated with the luminal membrane of the thick ascending loop. The organic acid transport system of the proximal tubule is primarily responsible.
3. Both
4. Neither
Concerning furosemide, choose the correct statement(s):
1. Most of the administered furosemide is excreted in the urine unchanged.
2. About a third of administered furosemide is metabolized by conjugation to the glucuronide derivative in the kidney.
3. Both
4. Neither
Generally, loop diuretics exhibit relatively short elimination half-lives.
1. True
2. False
One of the most important clinical indications for loop diuretic administration is in the management of acute pulmonary edema.
1. True
2. False
Indication/indications for loop diuretics:
1. In patients with mild hyperkalemia, loop diuretics can be helpful since these drugs enhance urinary excretion of K⁺ .
2. Loop diuretics may be helpful in increasing urine flow and promoting K⁺ excretion in acute renal failure.
3. Both
4. Neither
Loop diuretics may be helpful in shortening the duration of renal failure.
1. True
2. False
Loop diuretics may be helpful in managing toxicities associated with bromide, fluoride and iodide ingestion.
1. True
2. False