Anesthesia Pharmacology:  Serotonin Pharmacology

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Some Serotonin Receptor Subtypes

Receptor subtype

Distribution

Coupling mechanism; comments

5-HT1A

Raphe nuclei, hippocampus

cAMP, potassium channels:partially selective agonist:  8-OH-DPAT

5-HT1D(a,b)

Brain

cAMP,partially selective agonist:  sumatriptan (Imitrex)

5-HT3

Area postrema, sensory and enteric nerves

Receptor: Na+-K+ ion channel: partially selective antagonists  ondansetron (Zofran), granisetron (Kytril), tropisetron

5-HT4

CNS, ,smooth muscle

cAMP; partially selective agonists:  metoclopramide (Reglan)

Burkhalter, A, Julius, D.J. and Katzung, B. Histamine, Serotonin and the Ergot Alkaloids (Section IV. Drugs with Important Actions on Smooth Muscle), in Basic and Clinical Pharmacology, (Katzung, B. G., ed) Appleton-Lange, 1998, pp 261-286.

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