Anesthesia Pharmacology Chapter 22: Serotonin Pharmacology Practice Questions

Concerning serotonin (5-HT) metabolism, which one(s) of the following is/are correct?
1. The major metabolic route for 5-HT involves oxidative deamination by MAO-A.
2. Platelets which contain significant serotonin exhibit MAO-B as the major monoamine oxidase isoform.
3. Both
4. Neither
Primary serotonin localization in the CNS.
1. Cerebellum
2. Brainstem raphe nuclei
3. Neocortex
4. None of the above
Serotonergic raphe nuclei projections:
1. Spinal cord
2. Other brain sites
3. Both
4. Neither
Is due to number of serotonin (5-HT) receptor subtypes, the serotonergic system represents the largest neurotransmitter receptor family.
1. True
2. False
Characteristic(process) of the 5-HT1 serotonin receptor subtype family:
1. Activation of this receptor results in a reduction in adenylate cyclase enzyme activity.
2. These receptors affect the activity of both potassium and calcium ion channels.
3. Both
4. Neither
Serotonin receptor subtype found broadly distributed in the CNS, localized mainly and serotonergic nerve terminal regions.
1. 5-HT1
2. 5-HT2
This serotonin receptor family represents the only monoamine neurotransmitter acting as a ligand-gated ion channel.
1. 5-HT1
2. 5-HT2
3. 5-HT3
5-HT activity is mainly terminated by monoamine oxidase degradation.
1. True
2. False
This antidepressant agent blocks the serotonin reuptake transporter, the norepinephrine reuptake transporter or both.
1. Fluoxetine
2. Duloxetine
3. Venlafaxine
4. A & B
5. B & C
6. A & C
SNRIs and SNRIs: (some) clinical application(s):
1. Panic disorder
2. Fibromyalgia
3. Both
4. Neither