Anesthesia Pharmacology Chapter 22: Serotonin Pharmacology Practice Questions

Repinotan: which one(s) of the following statements is/are correct?
1. This agent is classified as a 5-HT1A agonist.
2. This agent, in clinical trials, it appears to reverse opioid-induced respiratory depression following morphine administration.
3. Both
4. Neither
Concerning melatonin:
1. Melatonin is a derivative of serotonin, following serotonin methoxylation and N-acetylation.
2. Melatonin interacts in the CNS by means of melatonin receptors, MT1 and MT2.
3. MT1 and MT2 represent receptors whose activity depends on coupling with the G protein signal transduction system.
4. A & B
5. B & C
6. A & C
7. A, B & C
Which one(s) of the following statements concerning sleep disorder treatment is/are correct?
1. Tasimelteon is approved for non-24 hour sleep-wake disorder.
2. Ramelteon is an approved drug for management of insomnia.
3. Both
4. Neither
This drug has been approved (European approval) for management of major depression.
1. Tasimelteon
2. Agomelatine
Activation of pain and itch sensory endings, causing some symptoms associated with insect stings.
1. Serotonin
2. Histamine
3. Both
4. Neither
Associated with the chemoreceptor reflex (a.k.a. Bezold-Jarsch reflex):
1. Some cardiac glycosides
2. Nicotinic cholinergic receptor agonists
3. 5-HT3 serotonin receptor activation
4. A & B
5. B & C
6. A & C
7. A, B & C
Concerning serotonin and platelets:
1. Serotonin is stored in platelet secretory granules
2. Serotonin is synthesized by the platelet
3. Both
4. Neither
In the case of damaged blood vessels to the point that vascular smooth muscle is exposed, serotonin (from localized platelets) induces vasoconstriction.
1. True
2. False
Aggregating platelets, for example at a injury site, results in serotonin release.
1. True
2. False
The principal response of blood vessels to serotonin is:
1. Vasorelaxation
2. Vasocontraction